Think for a moment about the last time you had a bad case of the flu: the headaches, the chills, the vomiting, the congestion, the depressed mood, the inability to function normally for days. But imagine it felt 10 times worse, and lasted for months or years, robbing you of anything resembling a truly human life.
That is life for the hundreds of millions of people who live with–and often die from–malaria.
The malaria parasite is one of nature’s cruelest torturers. Acquired from the bite of the common Anopheles mosquito, this parasite enters the bloodstream and, left to its own devices, wreaks havoc on the lives of its human hosts.
In its milder forms, the malaria parasite leads to cycles of different symptoms including fever, sweat and chills, muscle pains, shock, and breathing problems. More dangerous variants lead to liver failure, coma, and brain damage. And, of course, there are the deaths–millions and millions of individual lives ended prematurely, usually after enough suffering to make death a relief. The most common malaria deaths afflict the most vulnerable–children under 5, pregnant women, and individuals who are already weakened by malnutrition or other diseases.
When you hear of “living in harmony” with nature, remember this: nature gives us unmitigated malaria, while human ingenuity and industry gave us the ultimate weapon against malaria–the industrial, “artificial” chemical DDT. As the National Academy of Sciences said in the 1970s, “[T]o only a few chemicals does man owe as great a debt as to DDT…in little more than two decades, DDT has prevented 500 million human deaths, due to malaria, that otherwise would have been inevitable.”
In 1939, Paul Müller discovered that Dichloro-Diphenyl-Trichloroethane, or DDT, is an effective chemical agent against insects such as flies, mosquitoes, and beetles. ScienceHeroes.com gives a good account of the story.
Müller was an independent scientist often referred to in the labs as a lone wolf…Two events occurred that influenced his research into insecticides. The first was a severe food shortage in Switzerland, which demonstrated the need for better insect control of crops. The second event was the Russian typhus epidemic, the largest typhus epidemic in history. Müller, with his background in chemistry and botany, found himself both motivated and prepared for the challenge.
He worked for J.R. Geigy (which eventually became today’s drug giant Novartis), developing tanning methods for protecting clothes from insects, and a safe seed disinfectant that wasn’t based on poisonous mercury compounds, as was common in his era. After these successes, he decided to pursue the perfect synthetic insecticide. He absorbed all the information possible on the subject, came up with properties such an insecticide would exhibit, and set forth on his solitary quest to find it. After four years of work and 349 failures, in September of 1939, Müller placed a compound in his fly cage. After a short while the flies dropped and died. What he had found was DDT.
Others quickly used Müller’s work, which went on to win the Nobel Prize in Medicine, to combat insect-borne diseases. In one success story, 1.3 million people were treated with DDT to defeat a typhus epidemic in Naples during the winter of 1943/44 that no other treatment could stop. The DDT killed the lice that carried the disease, stopping the epidemic at its root. So began an epic war against nature’s deadliest insects.
DDT was a revolution in both effectiveness and safety. Prior to DDT and other modern pest control agents, pesticides typically included poisons such as arsenic or cyanide, which often did more harm than good. Because DDT was the result of industrial engineering and scientific selection aimed specifically at fighting bugs and benefiting humans, it provided a new level of effectiveness and safety. It could kill bugs but be eaten safely by humans.
DDT has numerous qualities desirable in an insecticide. It is a white, almost odorless powder that does not easily break down, even over long periods of time and is only slightly soluble in water. Once DDT was deployed in a given area, it could win enduring victories over deadly insects. Thus, it was used amply; direct deployment on the human body, spraying of parasite-infested areas, inside homes, mosquito-breeding waters, and large-scale deployment over crop fields were commonplace in the early years of use in the US.
Today great efforts are made to find a viable vaccine against malaria and to improve medical treatments for those who have contracted it. But the disease is not an easy target. There are many strains of the parasite and several variants of the Anopheles mosquito can serve as a carrier. Due to the short life-cycles of mosquitoes the malaria parasite can spread rapidly. Fortunately, DDT continues to prove reliable 70 years after its introduction, possessing a mixture of qualities unmatched by alternatives. Its longevity minimizes repeat treatments, further increasing reliability as well as affordability. Its safety for humans and animals makes it usable inside homes and close to potential malaria victims. And DDT has multiple ways of stopping deadly insects; even those that develop a resistance to its poison are still repelled by it.
The historical record is definitive on all these counts. In the decades following Müller’s discovery, DDT proved highly versatile at defeating insect-borne diseases. By the 1960s, thanks to widespread deployment of DDT, malaria was essentially eradicated in the developed world. Acquiring malaria in the Western world today is unthinkable, but in the 1930s it was commonplace. Malaria had been widespread even in industrialized countries, where it killed thousands every year and infected many more. The popular misconception that malaria is only a tropical disease is only plausible because DDT eradicated malaria from northern latitudes within a generation. And DDT’s beneficent impact went far beyond malaria. It has proved effective against many other insect-borne diseases, such as yellow fever and typhus.
Poor countries also benefited greatly from DDT. In Sri Lanka, malaria declined from 2.8 million cases and thousands of deaths in 1948 to fewer than 30 cases and zero deaths in 1964. In India the annual death toll declined from many hundreds of thousands in 1935 to about 1,500 in 1975.
The list of success stories in developing countries is lengthy. With few exceptions, DDT proves effective wherever it is used, and malaria cases spike where its use is discontinued.
A more recent example is South Africa, where DDT was successfully used for malaria control from 1946 to 1996. After switching to another insecticide the cases increased 80-fold. In 2000 DDT was reintroduced and demonstrated its effectiveness once more, reducing cases significantly from a peak in 2000-2001 of more than 60000 cases and more than 400 deaths to less than 6000 cases and only 37 deaths in 2007. The alternative pesticide–synthetic pyrethroids–was unable to match DDT’s results.
Unfortunately, despite the heroically positive impact of DDT, the modern environmentalist movement made this agent of life its number one target in the 1960s. In her famous book Silent Spring the environmentalist icon Rachel Carson chose, of all the features of industrial capitalism, DDT to demonize. Evading its benefits for billions, she made allegations about detrimental effects of DDT and other pesticides on human health and that of various other species (especially birds), based on junk science and anecdotes.
Revealingly, an intellectual and media establishment bred with anti-industrial hostility accepted Carson’s narrative. Blinded to the good of DDT and eager to seize on Carson’s bizarre characterization, they made her a cultural hero, which she remains today.
Although none of Carson’s claims could withstand scrutiny, not even those about birds, the damage in public opinion was catastrophic. In the late 1960s and early 1970s, environmentalist and conservationist groups such as the Audubon Society and the Sierra Club spearheaded a call for a DDT ban.
In 1972, after 7 months of investigation of DDT by the newly founded Environmental Protection Agency (EPA), EPA administrative law judge Edmund Sweeney ruled against a ban. He found, based on the science presented, that “DDT is not a carcinogenic hazard to man,” “DDT is not a mutagenic or teratogenic hazard to man,” “The use of DDT under the regulations involved here do not have a deleterious effect on freshwater fish, estuarine organisms, wild birds or other wildlife,” and that “The evidence in this proceeding supports the conclusion that there is a present need for the essential uses of DDT.”
But EPA head William Ruckelshaus, overruled Sweeney and banned DDT for general use, stating that “the long-range risk of continued use of DDT… is unacceptable and outweighs any benefits,” a statement based on blind anti-industrial ideology defying scientific evidence and decades of experience with widespread DDT use in the US and elsewhere.
Ruckelshaus never attended the 7 month investigation’s hearings. But he did apparently read Silent Spring; in his opinion and order he credited Rachel Carson’s book for raising awareness of the widespread use of DDT and other pesticides.
This marked a major political victory for the environmentalist movement. Although the case against DDT was not based on observable facts and sound science, the greens had acquired political influence.
Ironically, DDT’s success made it easier to demonize. As malaria and other diseases vanished from the industrialized world, the need for DDT was not as immediately perceivable. Western populations became more susceptible to scare stories about industrial chemicals, while oblivious to those chemicals’ life-saving benefits.
One example was the claim–often repeated today–that birds of prey, in particular the Bald Eagle, suffered from eggshell thinning and other effects of DDT, allegedly bringing them to the brink of extinction. As it turns out, the Bald Eagle had been threatened with extinction at least since the early 1920’s, more than 20 years before the first deployment of DDT, and increased in numbers during peak years of US DDT deployment. The connection between eggshell thinning or other detrimental effects and DDT could not be established by following scientific investigations.
Another common environmentalist critique of DDT is that insects develop resistance to it. (This claim was made by Greenpeace’s Ryan Rittenhouse in a recent debate with CIP’s Alex Epstein.) While resistance is a real problem with all chemicals used for controlling insect-borne diseases, DDT again proves superior to alternatives. In addition to its poisoning effect DDT also works as a repellent even if the insects have acquired resistance to it.
Even if these allegations were true they would not justify banning a pesticide with DDT’s track record of enormous benefits. The absence of facts behind the attacks on DDT indicates that environmenalists attack it not out of a concern for human safety, but on an ideological hatred of industrial chemicals.
Parallel to the propaganda efforts to demonize DDT as a dangerous and highly toxic substance, aid organizations and governments applied pressure to halt third-world countries from using DDT to save their citizens. A recent example is Uganda where in 2004 the EU threatened “dire consequences” for the country’s exports if the western anti-DDT standards weren’t met.
Influenced by donor agencies like the United States Agency for International Development (USAID), international bodies like the United Nations Environment Programme (UNEP), and other organizations, countries that depended on the aid were inclined to stop using DDT or not introducing it for disease-control. Belize and Bolivia, among others, have dropped the use of DDT out of fear of losing foreign subsidies.
Declining worldwide use of DDT also resulted in less availability for poor countries. India is the only country left producing DDT in large amounts. To combat this problem 15 African countries recently declared they would start producing the chemical for use against malaria mosquitoes.
Instead of encouraging the proven and effective DDT, a concerted effort was made to promote alternatives such as insecticide-impregnated bed nets and vaccines. The results failed to reach the promised levels. Subsequently, the World Health Organization (WHO), thanks to the influence of anti-malaria advocates on public opinion, changed its guidelines to encourage a more widespread use of DDT, acknowledging the unreasonable fear of environmental and health impacts. According to their own press release that constituted a “reversing” of their policy.
In 2001 at the Stockholm Convention to ban persistent organic pollutants (POPs), also named the “dirty dozen” and including DDT, environmental organizations demonstrated their opposition against DDT for any use. The World Wildlife Fund (WWF), Greenpeace, UNEP, Physicians for Social Responsibility, and many others advocated against an exemption allowing DDT use for human health. Thanks to resistance of developing countries and anti-malaria advocates they had to back down.
Despite recent efforts of environmental groups to re-write their history on DDT, the record is clear. Their advocacy against DDT was never based on facts and sound science but on their anti-industrial, ultimately anti-human ideology. Their stated goal was and continues to be to get rid of this marvellous chemical because it constitutes a fundamental modification of nature by man, not because it does actual harm that outweighs the benefits of its use.
The result of this ideology-driven campaign against the use of DDT is an re-emergence of malaria in places where it was believed to be under control and the continuing high death toll in places where it was not effectively used yet, namely sub-Saharan Africa, parts of South America and Asia.
At its peak malaria infected hundreds of millions of people and killed over one million every year during the past decades. Today it is estimated that still about 650,000 human beings die every year from it. Many of these victims could likely have been avoided had the campaign against DDT not taken place and the success story of this pesticide been allowed to continue and spread into the poorer regions of the world.
The only way to stop the carnage is to embrace DDT, and industrial progress more broadly, as agents of human prosperity and happiness.
Steffen Henne is a Researcher for the Center for Industrial Progress



Excellent article. Thank you for taking the time to provide background on DDT and it’s effectiveness.
The movie “Not Evil Just Wrong” is an excellent source of backup information for this article.
I need to make a clarification on my last post. Malarial iitfcenon is almost entirely a matter of human and some species of mosquito specific. There are some malarias which can cross species from our monkey cousins but they are very rare.However the mode of transmission of malaria from humans to mosquitoes would typically be from an infected human to an uninfected mosquito, where the protozoon does its work. The issue, as I recall from the article I read, is that when a mosquito extracts human blood it extracts whole blood, including red blood cells containing the malaria protozoa, which take enough time to digest in the mosquito’s gut that before those cells are digested,the immune response that started up in the red blood cells when iitfcenon occurred in the human host, continues in them long enough within the mosquito’s gut for the antigens produced by them to be released when the mosquito’s gut dissolves the red blood cells. Those antigens kill off the malaria protozoa at that stage or otherwise disrupt their reproduction, as I think sg @17 may have been referring to.
Bill Gates has made some that are well worth reading, and the Bill and Melinda Gates Foundatin pizoritrie vaccination spending over all else. I’ve no doubt once polio is eradicated (they’re hoping to do it by 2015) malaria will be next on the list.It’s worth remembering that even only partially effective vaccines can have a signifciant population benefit. I think there has been a lot of research in influenza that shows even quite poor effectiveness can have a population effect beyond just preventing disease in those directly vaccinated. It could be that partially effective vaccination plus prophylactic spraying will have a huge combined effect.
Great stuff! I remember years ago a boss of mine telling me that the banning of DDT was one of the worst tragedies in human history. Sadly, I had no idea at the time it was such a bad thing. My own research shortly thereafter revealed his words to be of little exaggeration.
Down and Out of Saigon, here is a diagram of . As you can see the tsmquioo picks up some gametocytes (?) from the human, so if you give the human the right chemicals you may be able to provoke an immune response in the mozzie. Or maybe you can just spray the tsmquioo? I think it’s worth bearing in mind that Bill Gates is exceptional as far as philanthropists go. Not only does he have fantabulous amounts of money, but he’s very smart and has a very, shall we say, non-American view of public health. He also obviously takes the responsibilities of rich people very seriously. But on top of that perhaps because of his experience in the computing world? he has a very clear idea of how institutions and governance structures serve to prevent or promote the public good. This makes him an ideal person to promote good results in aid. Just compare with the Koch brothers, whose pet project, the Cato Institute, is strongly opposed to the HPV vaccine, and never saw a government regulation it didn’t want to blame for the world’s ills. While those philanthropists are funding people to stridently demand the return of (largely useless) DDT, Gates is funding vaccine development and distribution. The difference in purpose and intelligence is obvious
Thank you for your input. The fact of the matter is that there is no effective vaccine on the market as far as the WHO tells us, DDT is effective and on some markets. It should be available to more. DDT is demonstrably not “largely useless”. And malaria would certainly be a much bigger problem today if it hadn’t been invented.
sg, quite right. I understand that work is being done on a vcinace which, while administered to humans, has its effect during that part of the malaria protozoas’ lifecycles when they are in mosquitoes. And if you also factor in artemisinin as an effective treatment (at least for a while before immunity is developed to it) there is a lot of reason to hope that with a lot of effort we could see malaria going out the back door as smallpox has and, hopefully, polio will. Then on to TB where bad trouble is brewing with drug resistant strains.
Rachel Carson has indirectly caused the deaths of as many people on our planet as the worst tyrants of the 20th century combined.
While DDT has an important purpose in saving many lives in malaria sticken countries there are reasons for the proposed bans, these chemicals are carcinogens and possible endrocrin disrupters, overall the biggest concern that we have today is bioaccumulation….a concept that was not understood in the 1950s and 60s when DDT was the insectcide of choice.
Tiff,
I would be very interested in finding solid research that would lead us to believe the claims that “…these chemicals are carcinogens and possible endocrine disrupters…”, in addition to “…bioaccumulation….a concept that was not understood…”. Can you help?
Dan
sg: how does one apply a vaccine to a muotsiqo host without killing it?D&O I think that I raised that idea and so I should answer your question. As I recall the article I read the idea was that the vaccine injected into humans would not have enough time to raise an immune response to the malaria protozoon when a human was injected by the malaria carrying muotsiqo but that the muotsiqo would carry away enough human blood (necessary for the next step in the protozoon’s development) and incubate it for enough time for the immune response to express itself while the protozoon is in the muotsiqo’s gut, killing the protozoon off then.Bear in mind that malaria is a parasite to a muotsiqo just as, and more so than, it is a parasite on us. For us malarial infection is serious and sometimes fatal. For a muotsiqo it is also a parasite and infection by it is always fatal to the muotsiqo it infects. It explodes the muotsiqo gut where it is incubating.
The US does have a strong titdraion of the seriously rich using their money to do things that benefit society. However, as Warren Buffet points out this should not be an excuse for undertaxing the rich.Thats true. Though as much as it might go against the typical view of the USA, I believe there’s more of a culture of giving to charitable causes. A quick google seems to indicate that on average USA people donate at about 4 times the rate of Australians (some of that is skewed by the really rich).When I lived in the US I was a bit surprised by some of the things that people on quite ordinary wages felt was an obligation to donate to eg donating money to the university they went to help fund scholarships. In Australia most people would think of that as something the government is responsible for.As an aside as I think I’ve mentioned before the best way to increase philanthropy of the wealthy in Australia is to reintroduce death duties. People will give money away rather than give it to the government
Are you serious? This guy is Pure Republican Rhetoric. DDT is a Good Thing! say’s he and you beviele this? What about the Eagles return after DDTs ban? along with many other Bird spieces? It was the first time I heard the Ban has been Lifted! where and when was the Mass Media *Fox news’ Chicago Tribune etc reporting this? By the way Owned By the Elitists. Whom now are doing there best to maintain the current systems. He argues, We make the nations Rich!Give me a Break! You RAPE the Nations and are Now on this PR campaign to Dupe those whomn would beviele your Elitist rhetoric. WAKE UP’ Both the Democratic and Republican parties are and Have been Bought by way of Campaign contributions and those elected Only serve the Interests of the Corporations OWNED by the Elitists. They say’ We will make YOU rich! Are you Now? for they’ve been in POPWER for decades. There is NO denying the Worlds Glaciers are melting. Be it by CO2 or Sunspots’ the cause remains Of less consequence than What we do about it! Do we have the Right or the Time to say’ We may continue as Usual? What if it IS CO2 and we continue pumping it into the atmosphere? Simple solutions are available such as Wind energy and Wave energies. The Oil comnpanies can yet’ Own the Monoplies If they just Diversify into these Platforms. No I do not have a great eduacation yet’ I can see Those whom have and control the Power Do everything possible to Retain it! This is simply there effort. Don’t buy the BS.
Yes, we are serious, no not “the” glaciers are melting, some are, some because of human influence, nobody can claim with any certaintity that it is because of human CO2, everyone who does is not a serious or informed individual. I’m not a Republican or Democrat. If you would read the piece and educate yourself, you would see that the effect of DDT on birds is neglectible and that’s observable fact.
Simple solutions are only available to the simple mind.
And yes, DDT is a GREAT thing.
Thanks for reading.
gregM, aren’t CSL also working on some kind of hemcical that targets the mosquitos reproductive behavior? I guess most people are thinking a mixture of techniques involving attacking both hosts, the environment and the parasite all at once is the best idea.Occam, for every cashed-up one percenter who is working to make the world a better place, there’s another one (like the Kochs) who is funding attempts to make it worse. Gates’s work is great, but it is almost always done in conjunction with governments and the NGO aid sector (he funds other people’s implementation programs, mostly) and his behavior is no proof that the corporate world is universally good.But then no one here is arguing that the corporate world is universally bad. Which is why your contribution to this thread is completely worthless.
While working in Nigeria I contracted a case of Malaria, and I can tell you first hand that this is one bad fever. I was unable to remember anything of the first two days, stayed in a bed in a hopital for over a week, then in a staff house bed until I had enough strength to be able to catch a flight back to the states. I was not the same person as prior to the fever for almost a year. My daily workout schedule was completely dropped, as I didn’t have enough strength to even finish my daily work load. My vision is still impaired to this. The really bad part is at times since then, under emense stress (physical), and heat, I have relapses of it, going through all of the same symptoms, only to a much lesser degree.
Thank you for this very informative essay.
Thank you all for your interest and kind words.
Bioaccumulation was not properly understood back then, that is correct. My guess it we do not properly understand it today, it is quite complicated in detail with all the metabolites, saturation and biochemical side effects etc. However, the cancer epidemic did not show up (as the effects on birds of prey did not). It is very hard to measure any effect on the population since living in a different geographical region can change your risk for cancer to a greater extent. But the real world observations do not confirm the scare stories at all, even after heavy usage of DDT in agriculture in the US.
In regard to cancer I would like to draw attention to the fact that “everything” is creating cancer. Cola (the soft drink) does, other human bodies do (we radiate because of radioactive isotopes in our tissue and bones). It is not a question of whether our environment has the potential to cause cancer. The numbers for most cases cannot be recreated outside the laboratory, however. You would have to drink that much cola to get even close to having a remotely measurable effect on your cancer probability that the water in the drink would kill long before (I think it was thousands of gallons per day).
You see, cancer scares are easy to produce.
Steffen
Bill Gates has been funding some in Australia.The Melinda and Bill Gates Foundation rdivoped most of the $18 million for a world-first experiment to control the spread of dengue fever in the Far North.The project is a massive international collaboration between research institutions in Australia, Vietnam, Thailand, the US and Brazil.The Cullingtons’ leafy front yard was ground zero for the release of hundreds of mosquitoes infected with Wolbachia, a naturally occurring bacteria that has been proven to block mozzies from infecting people with the potentially fatal virus.There may not yet be a proven human vaccine against dengue fever, but scientists have created a dengue vaccine for the mozzies.The US does have a strong tradition of the seriously rich using their money to do things that benefit society. However, as Warren Buffet points out this should not be an excuse for undertaxing the rich.
The US has already an extremely progressive income tax.
Dear Mother I understand it is arbusd, but we have the resources to fight many many illness that are not be treated in the proper way. And we are not using them. DDT is not the best choice, because we are leaving the problem to the processed in the next stage.You should remember how often in september the beach of El Perellf3 was suddenly taken by thousands of little birds flying away from their natural places because the massive human fumigation in the near rice grows.DDT is not the solution, the solution is to put energy (money) on that vaccines and treatments. Just one tomahawk missile, is a spend of 560.000 dolars. This is the cost of a unit of investigation, with a medium lab.But we (they are we in fact) are using buying and firing not just one missile.DDT as the pleyad of other chemics we are freeing into nature are comming back in the form of a failing inmune system in our sons and daughters.And as the Nuclear Garbage, we are confident in the next ones are going to learn how to deal with it.The problem is not about DDT is about what is the focus in our society. And obviously malaria and dengue are not the spot. Mainly because all that is not affecting us, and the effects beneffits the statu quo.DDT affects in some maner like the talidomina did, but silently. Because their effects over the DNA is slowt as noticeable. But truly are so dangerous. We cannot putting more and more thing to the account of the future generations. We must be responsibly now.We can find another remedies and ways, I’sure. It is just lasting the political will to do that. It is simple take the red pill or continue havin the blue one.
Holden, I think this is a very valid concern, iecpsally pertaining to organizations devoted to a very specific cause, such as malaria. If a vaccine for malaria does become available, there would be a need for the administration and organization of vaccinations. Since many of these organizations have established partnerships with communities, they would serve as the best liasion for the administration of vaccines. Of course, this would mean restructuring funding, their marketing plan, and personal. Thanks for sharing. Rob
DDT is extremely persistent. It is still showing up in the bodies of humans, though it was banned in 1972. It is showing up in the bodies of people born after 1972…. http://www.chem.duke.edu/~jds/cruise_chem/pest/effects.html
That’s true. It is not DDT that shows up in humans and animals, but some metabolites. And it is a good property of DDT that it is persistent. It means you need less of it to be effective and it is a cheap (very important in poor countries) way to fight insect-borne diseases. Persistency alone is not a problem, many chemicals, natural and artificial, are persistent. The long-term harm to public health that Carson and others alleged did not show up, however.